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While reading and correcting a PhD thesis on ‘flu virus I thought I would check what strains I have encountered.

In February 1978 after playing a match for what was then RC Hermance (now HRRC) on a Sunday. I fell ill on the Tuesday, called home and was picked up by my mother.  Unfortunately, though a very smart person, critical thinking was not part of her education, which stopped at 16, and she dabbled in homeopathy. So I got sicker, spent 4 days at 41°C or above, but happily was then under our local GP (my mum was not daft) and was receiving anti-pyrogenic injections.  That time is a bit hazy, though my mother did say she thought she would lose me, so I must have been pretty ill.  This turns out to be an H1N1 virus, which only affected those under 26 years old. As this article  argues this particular ‘flu virus seems likely to have emerged from a lab (bio warfare) accident in the USSR or from vaccination (infection?) tests with live virus in China or the USSR, since the strain was almost identical to that from 26 years earlier and had not been seen in the wild in the intervening quarter century.

Fast forward to 1999 and I get a call from Tristan Bernard, past teammate at RC Hermance (now Life President, well deserved, a true evangelist for the sport) asking for a bed for him and a mate who were watching the World Cup; Liverpool was on a commute between games. A great evening, stated off in the Vines, and finished with a meal sometime after 2 am. A few days later ‘flu – this was I think brought to the UK by an Australian supporter and was an H3N2 strain virus. Not a major health incident for me though, a few days in bed and I was fine.

So the worst that rugby has done for me is ‘flu, twice, though I do have a wobbly ankle joint too.

As a side issue the murky past of the 1978 H1N1 ‘flu virus highlights the stupidity of allowing the gain of function engineering of pathogens. Regardless of whether the 1977 ‘flu virus did re-emerge from a lab, accidents, by definition, happen and viruses such as ‘flu remain an obvious war tool. I would be far more worried by N. Korean efforts in the molecular biology of viruses than by a few missiles with nuclear warheads. The latter can be stopped in flight, whereas viruses cannot.

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A discussion today with a student asking about the use of the Royal “we” in a report about his work. I agree, this is wrong. My suggestions were the first person singular and the passive. The passive gets a bad press in places, but it does work; the repetition of “we” or “I” grates, the latter particularly so because it can convey a strong sense of ego. Though as I pointed out, this depends how it is used. It was common in single author papers for the author to use “I”. The practice has disappeared due to multiauthorship and the urge to make scientific observations look objective. We finished by joking about the feudalism implicit in the use of ‘my laboratory’, as if this was some sort of sentient being, and then I wondered out loud whether one might not, in a multiauthor paper state:

“In experiment X (Fig. X), blogs demonstrated that….” And then later “In experiment Y (fig. Y) Doe indicated….”

Tonight a tweet from @UtopianCynic

UtopianCynic tweet

reminded me of my earlier conversation. Indeed, why bother with all the rubbish associated with authorship position? Why not have a list of authors and in the paper report who did what and who thought what?

It would then be clear (i) who pulled together the original hypothesis; (ii) who did the experiments; (iii) who thought up the interpretations of the data.

I think I might try this out.

This also solves the long-standing problem of blaming whoever is at the bottom of the pile when a paper is found to have manipulated data. Someone will be explicitly on watch and someone else will have done a particular measurement under that person’s watch.

It will be obvious who should walk the plank, and reaching for lawyers will only result in keel hauling, because it will be all written down and signed off.

 

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Congratulations to Aiseta!

On Monday 4 December Aiseta Baradji successfully defended her thesis. A long journey and a hard one as ever with its ups and downs, surprises and a certain amount of head scratching over data that push us in new directions. In the end a great thesis that will be consulted in the labs of her supervisors for a long time. Now onto the next phase.

 

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A recent article on bioarchiv “Amending published articles: time to rethink retractions and corrections?” puts forwards ideas on how we might change the way we deal with retractions and corrections. (more…)

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Two postdoc positions are available in my lab.

Both are part of the larger, European Commission-funded FET-Open programme, ArrestAD, which has recently been funded.

Position 1 aims to characterise heparin-binding proteins in Alzhiemer’s disease.

Position 2 aims to develop inhibitors to Golgi sulfotransferases. (more…)

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ArrestAD

The ArrestAD team had its kick off meeting in Paris on 5 January 2017. This was held on Paris, the base of our coordinator, Dulcé Papy-Garcia and was hosted by the APHP in the Espace Scipion. Team members from outside Paris stayed at the Hotel La Demeure  situated nearby and though on the Boulevard St Marcel, nice and quiet.

The kick off meeting started with a presentation form our coordinator, which provided the backdrop for the day. Science presentations from the participants then followed. These provided an overview of the position of the field of the participant and then summarised research plans. In a multidisciplinary project, one cannot be fully up to speed with the other fields, so we all learned a lot. The more technical part of these presentations gave us an opportunity to discus the nuts and bolts of our research plans and how these fitted together. It…

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A little late this year, but then there are many calendars, so it is surely the start of the New Year for someone, somewhere, today. (more…)

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