Chris Miller, Professor of Molecular Neuroscience in the Departments of Neuroscience and Clinical Neuroscience at the Institute of Psychiatry, King’s College London will be giving his seminar on Monday 23rd of April, 1pm, LT3.
ents of Neuroscience and Clinical Neuroscience at the Institute of Psychiatry, King’s College London. His research focuses on the mechanisms of nerve cell death in Alzheimer’s disease and motor neuron disease (also known as amyotrophic lateral sclerosis -ALS). He is particularly interested in protein and organelle trafficking in neurons since there is evidence that these processes are disrupted in Alzheimer’s disease and ALS. Notably, transport of protein and organelle cargoes through axons (axonal transport) is an early pathological feature in these disorders. The early damage to axonal transport argues that defective axonal transport contributes to the disease process in a primary fashion and is not just some end-stage epiphenomena.
His group utilise cell, molecular, proteomic and advanced imaging methods including analyses of transgenic mice, to dissect the mechanisms that control transport of key Alzheimer’s disease and ALS related cargoes. They are also attempting to understand how insults associated with these diseases impact upon protein and organelle transport.