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Archive for January, 2019

An improved brace of sulfations


ArrestAD

After preprinting our two papers (here and here) on inhibitors of sulfotransferases they were submitted to Biochem J. The referees made some excellent suggestions – a bit of work, but the extra controls add even more certainty, which is never a bad thing.

The papers are published back to back.  The Biochemical Journal recognised the fundamental importance of the papers in opening up a new area of signalling  with an accompanying editorial by Sharon Yeoh and Richard Bayliss, as well as the issue cover.

Our papers describe the first high throughput assays for sulfotransferases, the enzymes that transfer sulfate from PAPS to their substrates. These assays were developed in parallel for three Golgi sulfotransferases; the two tyrosyl protein sulfotransferases, which sulfate selected tyrosines on proteins, and heparan sulfate sulfotransferase 2, one of the polysaccharide sulfotransferases responsible for the sulfation of heparanosan, and so producing the protein binding…

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