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Archive for March, 2012


Dr Tracey Gloster, Wellcome Trust Career Development Fellow a the Dept. of Chemistry, University of St Andrews will present a seminar on
“Development of inhibitors as┬áresearch tools for carbohydrate processing enzymes”

Monday March 26, 1pm LT2

Lunch in the Committee room, from ~12.00

Dave

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Since Chris Doty’s excellent paper on the synthesis of silver nanoparticles, we haven’t pushed on this front a great deal. More recent exploration of these materials by Paul Free at IMRE showed that the standard routes to assembling a ligand shell on silver nanoparticles caused problems. Paul’s new paper shows how to resolve these issues by an adaptation of buffer and electrolytes used during the assembly of the ligand shell. The paper also shows that the silver nanoparticles are extremely robust in terms of ligand exchange with small thiols and that we can monofunctionalise them. We can now look forward to deploying these in real-world biological measurements and rationally building assemblies of silver nanoparticles.

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Seminar on drug design


Today’s seminar speaker is Dr. Glyn Williams, Astex Pharmaceuticals

LT3, Life Sciences Building 1 pm

Title: Like It Hotter – exploring the thermodynamic consequences of fragment-based drug design

Lunch beforehand in the Committee Room, as usual

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Our review, “Long-term tracking of cells using inorganic nanoparticles as contrast agents: are we there yet?” has been published online by Chemical Society Review. Details and links to the article are on Rapha-z-lab’s blog.

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Monday 12th of March, 1pm, LT3

Lunch beforehand in the committee room.

Laurence Pearl FRS is Professor of Structural Biology in the Genome Damage and Stability Centre and heads the School of Life Sciences at the University of Sussex. His laboratory studies the structural biology of DNA repair, signal transduction (the process by which a cell converts one kind of signal or stimulus into another) and molecular ‘chaperones’. Professor Pearl’s seminal contributions to scientists’ understanding of the recognition and repair of DNA damage and the function of molecular chaperones was recognised in 2008 with his election as a Fellow of the Royal Society (FRS). He is also a Fellow of the Academy of Medical Sciences and an elected member of the European Molecular Biology Organisation (EMBO). In 2011 he was the recipient of an Inaugral Wellcome Trust Senior Investigator Award.

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