Archive for the ‘Development’ Category

Ruoyan’s paper on “Diversification of the structural determinants of fibroblast growth factor-heparin interactions; implications for binding specificity” has been accepted for publication at the Journal of Biological Chemistry. The heart of her PhD thesis, this paper takes a hard look at the specificity of the interactions of six FGFs spanning five subfamilies with heparin and allied polysaccharides. She dissects the sites in the FGFs that are responsible for binding the sugars using the “Protect and Label” approach and the sites in the sugar that the FGFs binds using a combination of DSF, SRCD, biosensors and sugar libraries. As ever in biology, in important regulatory interactions there isn’t one binding site, instead these FGFs recognise what are best described as families of consensus sites in the sugar. Specificity in these consensus binding sites is elegantly illustrated by PCA and specificity maps to the evolutionary relationships of the FGFs.

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Prof Uwe Straehle from the Karslruhe Institute of Technology will deliver a seminar entitled “The zebrafish as a model for development and maintenance of the nervous system and the musculature”at 2 pm on Thursday August 30 in LT3, Life Sciences Building.

Uwe Straehle works on the regeneration of the muscular and nervous systems in zebrafish. A major focus of his work is the elucidation of the genetic networks controlling the differentiation, function and responses to environmental insults of these tissues.

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