• Home
  • Development of Heparin and HS Glycotherapeutics
  • Lab
  • People

Ferniglab Blog

The personal blog of Dave Fernig, thoughts on science and unrelated matters

Feeds:
Posts
Comments
« In Defence of REF
Its Science Jim, but not as we know it »

“Analysis of the FGFR Signalling Network with Heparin as Co-Receptor”

April 20, 2013 by ferniglab


Ruoyan’s paper on “Analysis of the FGFR Signalling Network with Heparin as Co-Receptor: Evidence for the expansion of the core FGFR signaling network” is out.

I am rather late with this post – the paper came out a month ago and I am usually quicker off the mark. The analysis was developed by Ed Yates, as part of our ambition to try to unravel the question of specificity of function, using the fibroblast growth factors (FGFs) as our model. A good model I would argue. Invertebrate animals have two or three FGFs, mammals 22, of which 18 count as “true” or “real” FGFs, that is they are extracellular effectors. What is particularly intriguing is that different FGFs do quite different things, at least according to the labels we use to describe molecular function. Some are outright hormones, while others are morphogens, and so on. The analysis takes in the specificity of FGFs for their different receptors and for their co-receptor heparan sulfate, using heparin as a model for the latter. Despite specificity being rather loose, so not simply 1 to 1, it is there and seems to reflect the evolution of the FGFs.

This is a first instalment. Ruoyan’s successors in the lab are working their way through the FGFs we have not analysed. By the time we make our biennial pilgrimage to the next FGF Gordon Research Conference in March 2014 we will have a lot more to say on this front.

Advertisement

Share this:

  • Twitter
  • Facebook
  • LinkedIn

Like this:

Like Loading...

Related

Posted in Fibroblast growth factor, Glycobiology | Tagged FGF, Fibroblast growth factor, glycosaminoglycans, heparan sulfate, heparin, science | 2 Comments

2 Responses

  1. on December 31, 2013 at 5:28 pm Sugary end of year thoughts | Ferniglab Blog

    […] who did much of the work. There is Ruoyan and Ed’s analysis of FGF interactions in FEBS Journal at the start of the year and then Quentin’s paper on the heparin binding protein network of […]


  2. on June 12, 2015 at 3:19 pm Of nanoparticles, cells and polyanions | Ferniglab Blog

    […] determines whether proteins will bind or not (posts on some papers I have been involved in here, here, and […]



Comments are closed.

  • Places of interest

    The one and only PhD comics, the guide to being a graduate and to mentoring.

    Improbable Research and the Ig Nobels

    Retraction Watch provides updates on retractions of articles.

    Office for Research Integrity, their video should be compulsory for all.

    Centre for Alternative Technology

    Lateral Science, has some quite stunning information - well worth a browse.

    Fascinating places that have been closed by lawyers

    Science Fraud, shut down due to legal threats on Jan 3 2013. and Abnormal Science

  • Blogroll

    • WordPress.com
    • WordPress.org
  • Funding agencies

    • Biotechnology and Biological Sciences Research Council
    • Cancer and Polio Research Fund
    • Engineering and Physical Sciences Research Council
    • Liverpool Pancreas NIHR Biomedical Research Unit
    • Medical Research Council
    • North West Cancer Research
  • Seminars

    • Cancer Research UK Centre
  • April 2013
    M T W T F S S
    1234567
    891011121314
    15161718192021
    22232425262728
    2930  
    « Mar   May »
  • Archives

    • November 2022
    • July 2022
    • April 2022
    • March 2022
    • May 2021
    • March 2021
    • August 2020
    • June 2020
    • April 2020
    • March 2020
    • December 2019
    • October 2019
    • July 2019
    • May 2019
    • April 2019
    • January 2019
    • September 2018
    • August 2018
    • May 2018
    • April 2018
    • February 2018
    • January 2018
    • December 2017
    • November 2017
    • July 2017
    • June 2017
    • April 2017
    • March 2017
    • January 2017
    • October 2016
    • June 2016
    • May 2016
    • March 2016
    • January 2016
    • December 2015
    • July 2015
    • June 2015
    • May 2015
    • March 2015
    • February 2015
    • January 2015
    • December 2014
    • November 2014
    • October 2014
    • September 2014
    • August 2014
    • July 2014
    • June 2014
    • February 2014
    • January 2014
    • December 2013
    • October 2013
    • September 2013
    • August 2013
    • July 2013
    • June 2013
    • May 2013
    • April 2013
    • March 2013
    • February 2013
    • January 2013
    • December 2012
    • November 2012
    • October 2012
    • September 2012
    • August 2012
    • July 2012
    • June 2012
    • May 2012
    • April 2012
    • March 2012
    • February 2012
    • January 2012
    • November 2011
    • October 2011
    • September 2011
    • August 2011
    • July 2011
    • June 2011
    • May 2011
    • April 2011
    • March 2011
    • February 2011
    • January 2011
    • December 2010
    • November 2010
    • October 2010
    • September 2010
    • August 2010
  • Follow me on Twitter

    My Tweets
  • Cloud

    American Civil War antithrombin III banana Biological imaging biotechnology Brexit Choanoflagellates chocolate chondroitin sulfate coagulation Confederate States covid19 DN Lee Education EU EU referendum Europe extracellular matrix FGF Fibroblast growth factor Food FRET sensors Gish Gallop glycosaminoglycans GMO government Graduate students heparan sulfate heparin history of science imaging Irvine Stephens Bulloch James Bulloch James Dunwoody Bulloch Liverpool microbiology Nanoparticle Nanoparticles Nanotechnology neuroscience nmr Open Access Open Data orange Parliament Peer Review PhD polysaccharide port sunlight Post publication peer review protein chemistry REF research Research Excellence Framework Research integrity Roast SARS-CoV-2 science Science and Technology Committee Science fraud Science Funding Science progress Scientific American Seminars sorbet speaking strawberry sulfation Sulfotransferase synthetic biology Teaching technology transfer Tourism Travel Universities

Blog at WordPress.com.

WPThemes.


Privacy & Cookies: This site uses cookies. By continuing to use this website, you agree to their use.
To find out more, including how to control cookies, see here: Cookie Policy
  • Follow Following
    • Ferniglab Blog
    • Join 73 other followers
    • Already have a WordPress.com account? Log in now.
    • Ferniglab Blog
    • Customize
    • Follow Following
    • Sign up
    • Log in
    • Copy shortlink
    • Report this content
    • View post in Reader
    • Manage subscriptions
    • Collapse this bar
%d bloggers like this: