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Archive for December 3rd, 2012


LT1 at 1 pm
Prof Dave Allsop from Lancaster University will give a seminar entitled “Protein oligomers as toxins, biomarkers and molecular targets for neurodegenerative disease”

Buffet lunch will be available in the Committee Room from 12 noon.

The formation of fibrillar aggregates from a range of different proteins is a common feature of numerous different ‘protein conformational’ diseases. In these diseases, normally soluble proteins are deposited in the form of insoluble fibrils inside and/or outside of cells. In the systemic amyloidoses, extracellular fibrillar deposits (often called amyloid) can be found in many different tissues and organs throughout the body. Localised deposits are found in some other diseases, such as late-onset diabetes, where they are restricted to the pancreas, and some important neurodegenerative diseases, where they are often found only in the brain. Examples of the latter include Alzheimer’s disease, Parkinson’s disease, the prion diseases (e.g. CJD in humans), Huntington’s disease, frontotemporal dementia and motor neuron disease. David’s  research is concerned with the pathological role of these misfolded proteins, and is focussed mainly on neurodegenerative disease and late-onset (type 2) diabetes.

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Professor Philip Moriarty from the University of Nottingham, who is a specialist in scanning probe microscopy, especially STM, has weighed in with an opinion. It should be stressed that this is entirely external and so is most welcome. As he points out, other analyses, e.g., 2-D NMR, may or may not hold up the hypothesis. This reinforces my earlier call for specialists in the different measurement modalities used to measure the orgnisation of ligands on the nanoparticle surface to bring their expertise to bear.

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