College of Life Sciences, University of Dundee
PTEN, PI 3-kinase and cancer
Monday March 5
Cellular signal transduction is the process by which cells coordinate their behaviour in response to their external surroundings including incoming signals, such as hormones and growth factors. The PI 3-kinase/PTEN signalling pathway is a key regulator of cell growth, survival and motility in many cell types and loss of control over its activity is a characteristic of most types of cancer and many other diseases, such as type 2 diabetes. Our work aims to understand in more detail the workings of the proteins that make up the core of this pathway, and the lipid signalling molecules that they synthesise and metabolise. We use a variety of approaches from enzymology, proteomics and lipid biochemistry to functional studies in cultured cells and in vivo.