Archive for February 29th, 2012

My previous entry on this subject, “Research Integrity“, was stimulated by the breaking news in October 2011 of problems surrounding publications from Prof. Melendez when he was at NUS. I have recently discovered that, following an internal investigation at the University of Liverpool, Prof. Melendez resigned from the University some months ago (late autumn or during the winter, I am not entirely sure). I am not au fait with the legal niceties, but I think the University should be proud that it has managed to resolve effectively the issue at Liverpool.

Update 3 November 2013 The links to Abnormal Science and Science Fraud are dead.

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Signalling seminar Monday March 5

Nick Leslie
College of Life Sciences, University of Dundee

PTEN, PI 3-kinase and cancer

Monday March 5
LT 2
Cellular signal transduction is the process by which cells coordinate their behaviour in response to their external surroundings including incoming signals, such as hormones and growth factors. The PI 3-kinase/PTEN signalling pathway is a key regulator of cell growth, survival and motility in many cell types and loss of control over its activity is a characteristic of most types of cancer and many other diseases, such as type 2 diabetes. Our work aims to understand in more detail the workings of the proteins that make up the core of this pathway, and the lipid signalling molecules that they synthesise and metabolise. We use a variety of approaches from enzymology, proteomics and lipid biochemistry to functional studies in cultured cells and in vivo.

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