Archive for February 27th, 2012

Monday 27 February
SR2 (might be LT3)
Christoph’s lab is interested in how cells sense mechanical and biochemical stimuli. Sensing of such stimuli is directed by adhesion receptors (integrins) that transduce the information of the extracellular environment via focal adhesion proteins to the actomyosin machinery. Coupling and uncoupling events between the integrins and the actin cytoskeleton and the coordinated recruitment and release of focal adhesion components are essential for polarized cell migration. In my talk I will present mostly unpublished data where we use a variety of imaging techniques and Atomic force spectroscopy to elucidate molecular mechanisms of cell adhesion and migration. I will present how the adaptor protein vinculin is involved in the transduction of forces and how it coordinates the assembly and disassembly of adhesion complexes.

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