Archive for September 27th, 2010

The latest paper from the Liverpool-Ronzoni collaboration illustrates that the notion of specificity in protein-heparin/heparan sulfate interactions is far more complex than 1 protein:1 sugar sequence. This opens up some real opportunities for the screening of novel compounds that will alter growth factor/cytokine/chemokine activity in disease!
Rudd, T.R., et al. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: Implications for sequence-activity relationships. Org. Biomol. Chem., DOI 10.1039/C0OB00246A.

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